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Clinicians should adopt more aggressive strategies for tongue leukoplakia patients with a history of head and neck cancer. These results may help clinicians gain a better understanding of oral tongue leukoplakia. These results may help clinicians gain a better understanding of oral tongue leukoplakia. We aimed to determine the immunolocalization patterns of the interleukin (IL)-6 signaling complex in epithelialized and non-epithelialized apical lesions of endodontic origin (ALEOs). Epithelialized (n = 8) and non-epithelialized (n = 7)