https://www.selleckchem.com/pr....oducts/nsc697923.htm
he gene segments of influenza A(H5N8) viruses reassorted extensively between the outbreaks. In this study the 2014-15 polymerase complexes were found to be more active, which is counterintuitive with the observed higher virulence of the 2016-17 viruses. Interestingly, the 2014-15 polymerase complexes also induced higher levels of IFNβ. These findings suggest that the higher virulence of influenza A(H5N8) viruses from the 2016-17 outbreak may be related to the lower induction of IFNβ. An attenuated interferon response could lead to inc
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