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BACKGROUND Metabolic syndrome is a complex pattern of disorders which occur jointly and is associated with increased risk of cardiovascular and cerebrovascular disease. Therefore the need for more-efficient options of treatment has become imperative. OBJECTIVE This study examined the effect of dietary-melatonin in the management of behavioural, metabolic, antioxidant and organ changes due to high-fat/high-sugar (HFHS) diet- induced metabolic syndrome in mice. METHODOLOGY Mice were randomly-assigned into five groups of ten animals each.