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When adjusted for age, gender, and stage, the 20-gene peritoneal signature proved to have prognostic value for both OS [adjusted HR for the high-risk group (vs. low-risk) 2.32 (95% confidence interval, CI, 1.69-3.19; 0.0001)] and for DFS [adjusted HR 2.08 (95% CI, 1.50-2.91; 0.0001)]. Our findings indicated that the activation of "stemness" pathways and adaptation to the peritoneal-specific environment are key to early stages of peritoneal carcinomatosis. The analysis suggested that this 20-gene peritoneal signature may hold p
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