https://www.selleckchem.com/pr....oducts/pf-07321332.h
We also found that AIM2, which encodes an important inflammasome component that triggers skin inflammation, is a direct target of FRA1 and/or activator protein-1. Our study provided clear insights and resources for an improved understanding of the pathogenesis of psoriasis. These disease-associated accessible regions might serve as therapeutic targets for psoriasis treatment in the future.Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect their target
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