https://www.selleckchem.com/pr....oducts/nutlin-3a.htm
Cisplatin is an alkylating agent that inhibits DNA replication and interferes with proliferation of cancer cells. However, the major limiting factor for its use is the possible development of adverse effects, including ototoxicity. Up till now, the mechanisms of this ototoxicity remain poorly understood. However, induction of oxidative stress and activation of the inflammatory cascade were suggested as contributing factors. The aim of this study was to explore the effect of L-arginine on cisplatin-induced ototoxicity in rats. Thirty m
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