https://www.selleckchem.com/pr....oducts/gsk2830371.ht
The results of simulations agree with experimental measures of the vasculature density in tumors, even in the case of particularly hypoxic tumors.While resistance mutations are often implicated in the failure of cancer therapy, lack of response also occurs without such mutants. In bladder cancer mouse xenografts, repeated chemotherapy cycles have resulted in cancer stem cell (CSC) enrichment, and consequent loss of therapy response due to the reduced susceptibility of CSCs to drugs. A particular feedback loop present in the xenograft
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