https://ralimetinibinhibitor.c....om/the-consequence-r
NLRP3-activating stimuli disrupted endosome trafficking and triggered localization of NLRP3 to vesicles good for endolysosomal markers and also for the inositol lipid PI4P. Chemical disruption of endosome trafficking sensitized macrophages towards the NLRP3 activator imiquimod, driving enhanced inflammasome activation and cytokine release. Collectively, these information suggest that NLRP3 can feel disruptions in the trafficking of endosomal cargoes
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