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(all p less then 0.05). Spatial-temporal analysis detected high-value clusters, the most likely cluster located at rural countries in the northern parts of Chongqing, from January, 2015 to July, 2017. (p less then 0.01). Besides, some urban districts were also found high incidence of severe HFMD cases according to the incidence maps. Conclusions The detection of clinical risk factors and the temporal, spatial and socio-demographic distribution epidemiological characteristics of severe HFMD contribute to the timely diagnosis and intervent
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