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Thus, As3mt and Mth1 have important differential roles in the accumulation of DNA damage linked to the transformation process while As3mt contributes to the genotoxic effects before the transformation, Mth1 prevents the DNA damage fixation after the acquisition of the oncogenic phenotype. This study demonstrates the influence of As3mt and Mth1 in arsenic DNA damage induction and it is the first to present Mth1 as a candidate modulator biomarker of the tumoral phenotype.Hydraulic fracturing (fracking) is a process used to recover oil and
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