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c agents allowing controlled vasodilation without excess diuresis at one end of the spectrum and effective diuresis without excess blood pressure lowering at the other. The present study investigates the effects of atrial natriuretic peptide (ANP) analogues engineered for exclusive vasodilatory or diuretic activities in experimental HF, and demonstrated the variants differentially exerted blood pressure and volume-eliminating actions.These peptides offer a unique treatment strategy which could fill the gap in current ADHF therapy by provi
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