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This amends previous observations that tsRNAs guide Argonaute proteins to silence their targets via a miRNA-like 5' seed match and suggests a yet unknown mechanism of regulation. Finally, our data suggests that some 5' tRHs are also able to sequence-specifically stabilize mRNAs as upregulated mRNAs are also significantly enriched for 5' tRH target sites. Published by Cold Spring Harbor Laboratory Press for the RNA Society.Macrolides are one of the most successful and widely used classes of antibacterials, which kill or stop the growth o
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