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The book model is used through steered and unbiased MD simulations to the recently resolved whole structure of KvAP. The simulations reveal that the resting condition requires a re-orientation of the S5 α-helix by ∼ 5-6 degrees in respect to your regular associated with the bilayer, that could result in the constriction and closure associated with the selectivity filter. Our findings offer the idea that the breakage of S4 under (hyper)polarization is a general f
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