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Statement of problem Information about the accuracy of maxillary and mandibular denture bases made with different fabrication techniques under uniform test conditions is lacking. Purpose The purpose of this in vitro study was to evaluate the denture base adaptation of computer-aided design and computer-aided manufactured (CAD-CAM) milled, 3D printed, and conventional heat-polymerized resin fabrication techniques. Material and methods Maxillary and mandibular edentulous models fabricated from cobalt-chromium alloy were scanned, and 2-mm