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The digital databases of Ovid MEDLINE, PubMed, EMBASE, Cochrane Library database had been methodically searched using the indicated keywords from their particular inception to April 2020. The chances ratio (OR) or mean difference (MD) with 95% self-confidence period (CI) had been utilized to analyze the info. Heterogeneity across analyzed studies was examined with chi-square test and I also Long non-coding RNA (lncRNA) as an essential regulator happens to be demons