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To determine whether admission venous plasma lactate concentration, serially calculated lactate variables, or the Acute Patient Physiologic and Laboratory Evaluation (APPLE ) score could discriminate hospital survivors from non-survivors in dogs presenting to the emergency department with clinical signs of shock. Prospective case series performed over a 24-month period. Large urban private teaching hospital. Seventy-one dogs admitted to the ICU with initial peripheral venous plasma lactate concentration2.5mmol/L and clinical and he