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Changes in SpO2 and AHI were examined in subgroups with mild versus marked nocturnal SpO2 and low versus high AHI during exposure to HA and compared between subgroups. Results Compared with SL, the mean nocturnal SpO2 was lower (p less then 0.0001) and AHI was higher (p less then 0.0001) at HA. The mean nocturnal SpO2 increased progressively (p less then 0.001), whereas AHI remained high (p less then 0.978) and relatively unchanged over nine successive nights at HA. Those with markedly reduced SpO2 upon arrival at HA exhibited pr