https://www.selleckchem.com/pr....oducts/pf-03084014-p
However, the size of supramolecular FEL-βRA better matched that of active cavity of BSA; the cocrystal is closely bound to BSA through hydrogen bonding with ASN390 residue and intermolecular hydrophobic interactions with LEU429, VAL432, LEU452 and ILE387 residues. This change on binding affinity of FEL to BSA induced by cocrystallization with βRA provided theoretical basis to evaluate the transportation, distribution and metabolism of cocrystal drug.Oxygen atoms have a lone pair of electrons, so they have high chelation a
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