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Pharmacologic anti-hypertensive (HT) treatment reduces cardiovascular risk. However, many patients are non-adherent due to perceived or real concern about sexual-related side-effects. In a subset of the SPRINT (a randomized trial of intensive versus standard blood-pressure control) trial, we sought to investigate the impact of anti-HT treatment on sexual activities of men and women over time, and whether this impact varied with a more or less intensive anti-HT therapy. Random-effects models for panel/longitudinal data. Among the 1268 me