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ctDNA variants maybe not identified in tissue samples should be thought about in MRD test. To explore the relationship between filial responsibility and caregiver despair across cultures. Twelve databases were reviewed for dissertations and peer-reviewed articles on filial responsibility and caregiver depression among adult children, posted before January 2020. In total, 476 titles and abstracts had been retrieved. Final analysis included six scientific studies; of those, four had been included in the