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Several elements of novelty (i-iv) are pointed out in the "conclusions" section (e.g., considering the continuously added biomass as a control variable during FBR).Women carriers of pathogenic variants (mutations) in the BRCA1/2 genes face a high lifetime risk of developing breast cancer (BC) and/or ovarian cancer (OC). However, metabolic factors may influence BRCA penetrance. We studied the association of metabolic factors with BRCA1/2 variants and the risk effect of metabolic exposures in relation to the position of the mutations wit
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