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Clinically meaningful cutoff values for changes in PAC-SYM and PAC-QOL scores were determined using receiver operating characteristic (ROC) curves. Data from 1095 patients (549, naldemedine; 546, placebo) were analyzed. The area under the curve for the ROC curves (ranges 0.719 to 0.798, PAC-SYM, and 0.734 to 0.833, PAC-QOL) indicated that both instruments can discriminate responders and non-responders for each anchor. PAC-SYM cutoff values ranged from -1.04 to -0.83; PAC-QOL cutoff values ranged from -0.93 to -0.82. Based on data deriv
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