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8%) models. Treatment effect size based on endoscopic improvement (≥50% reduction in SES-CD from baseline) was highest with the 2 models incorporating the LR and 1 to 2 CRs (Δ = 16.2%). Further, in the etrolizumab arm, models with 2 readers demonstrated the lowest variability on the SES-CD. Conclusions Central endoscopy reading models in CD impact placebo response rates and effect size. Incorporating the local reader appears to be important as models using both central and local readers resulted in the greatest treatment effect size fo
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