https://www.selleckchem.com/pr....oducts/Dasatinib.htm
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pR and the other two members of the RB family, p107 and p130. This process is controlled by a balance in the action of kinases, such as the complexes formed by cyclin-dependent kinases (CDKs) and cyclins, and phosphatases, mainly the protein phosphatase 1 (PP1). However, while the phosphorylation of the RB family has been largely studied, its dephosphorylation is less known. Phosphatases are holoenzymes formed by a cata
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