https://www.selleckchem.com/pr....oducts/z-vad(oh)-fmk
Background and aims Neutrophil infiltration is a hallmark of nonalcoholic steatohepatitis (NASH), but how this occurs during the progression from steatosis to NASH remains obscure. Human NASH features hepatic neutrophil infiltration and upregulation of major neutrophil-recruiting chemokines (e.g., CXCL1 and IL-8). However, mice fed a high-fat diet (HFD) only develop fatty liver without significant neutrophil infiltration or elevation of chemokines. The aim of this study was to determine why mice are resistant to NASH development a
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