https://www.selleckchem.com/pr....oducts/Abitrexate.ht
OBJECTIVE Enhanced expression of PAI-1 (plasminogen activator inhibitor-1) has been implicated in atherosclerosis formation in humans with obesity and metabolic syndrome. However, little is known about the effects of pharmacological targeting of PAI-1 on atherogenesis. This study examined the effects of pharmacological PAI-1 inhibition on atherosclerosis formation in a murine model of obesity and metabolic syndrome. Approach and Results LDL receptor-deficient (ldlr-/-) mice were fed a Western diet high in cholesterol, fat, and sucros
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