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Medication For ADHD - What Are the Side Effects? Many people who suffer from ADHD have their symptoms improved through medication. Every person's reaction to medication is different, and side effects are sometimes problematic. Methylphenidate is a stimulant. It works by raising levels of a substance in the brain that aids in controlling the behavior and attention. Stimulant drugs Stimulant medication improves attention and concentration for 70% to 80% of children a