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In this respect, it absolutely was stated that numerous antipsychotic medicines work as inverse agonists of D1R-like constitutive task. Having said that, D1R is extremely expressed in the medial prefrontal cortex (mPFC), a brain location with important features such as for instance working memory. Right here, we studied the effect of D1R-like constitutive activity and chlorpromazine (CPZ), an antipsychotic medicine and D1R-like inverse agonist, on different neuronal CaV conductances, and
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