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The consequence of drug-DNA binding constant (K = 1.26 × 106) indicated that there was a significant interaction between ETO and DNA with the intercalation mechanism. The modeling and simulation of experimental families of current-time (I-t) curves of dimeric voltage-gated proton channels and of proton-conducting voltage sensing domains (VSDs) with a minimum of free parameters requires the movement of protons to be controlled by the rate of increase of the Boltzmann open probability p over time in passing from the holding to the depola
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