https://www.selleckchem.com/
Silencing the RRM2 gene led to significantly greater cell survival (80%) compared with the control group ( = .003), whereas overexpression of the RRM2 increased viral oncolysis by 33% ( .001). Our results show that the oncolytic effects of MYXV correlate directly with RR expression levels and are enhanced in STS cell lines with naturally occurring or artificially induced high expression levels of RR. Myxoma virus holds promise in the treatment of advanced soft tissue cancer, especially in tumors overexpressing RR. Our results show that the oncolytic
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