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Arthritis and tendonitis were both rare. Vincristine neuropathy, MSK impacts from central nervous system pathology, and bone or joint pain from underlying cancer were the most common diagnoses. Multivariate analysis demonstrated that having rALL (odds ratio [OR] 2.00, 95% CI 1.07-3.76, p=.03) or obesity (OR 2.10, 95% CI 1.12-3.95, p=.02) were risk factors for MSK impairment at study entry. MSK impairments are common in this intensively treated patient population, especially in those with rALL and those who are obese. MSK impairments are common in this inten