https://www.selleckchem.com/pr....oducts/LDE225(NVP-LD
G-1 also impairs gallbladder emptying, leading to sluggish gallbladder motility and promoting the development of biliary sludge in the early stage of gallstone formation. The prevalence rates of gallstones were 80% in wild-type and ERα (-/-) mice treated with G-1 compared to 10% in wild-type mice receiving no G-1. However, no gallstones were formed in GPR30 (-/-) mice even treated with G-1. We conclude that GPR30 produces additional lithogenic actions, working independently of ERα, to increase susceptible to gallstone formati
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