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Even after careful autopsy, a proportion of sudden deaths, which range from 2 to 54percent, remain unexplained and this broad range of values is likely because of the heterogeneity of autopsy protocols. Post mortem diagnosis of cardiac amyloidosis nevertheless presents a challenge for forensic pathologists. Detailed morphologic study associated with heart and a complete histopathologic study are mandatory. Immunohistochemistry is really important for amyloid subclassification

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