https://www.selleckchem.com/pr....oducts/baf312-siponi
Background The most commonly used switching ratio from parenteral to oral methadone is 12. Methadone is highly bioavailable and a lower ratio might result in similar analgesia with less toxicity. Objective To compare success and side effects with two ratios from parenteral to oral methadone 12 versus 11.2 in hospitalized patients with cancer pain. Design A multicenter double-blind randomized clinical trial. Settings/Particiants Inpatients with well-controlled cancer pain with parenteral methadone requiring rotation to the oral
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