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https://www.selleckchem.com/pr....oducts/bms-986365.ht
All three compounds showed good biological activity as predicted by the model and confirmed by the docking studies.Protein arginine methyltransferase 5 (PRMT5) belongs to a family of enzymes that regulate the posttranslational modification of histones and other proteins via methylation of arginine. Methylation of histones is linked to an increase in transcription and regulates a manifold of functions such as signal transduction and transcriptional regulation. PRMT5 has been shown to be upregulated in the tumor environment of several

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