https://www.selleckchem.com/products/LBH-589.html
RNA-sequencing analysis systematically demonstrated a prominently aggravated lipid metabolism disorder, inflammation and fibrosis resulted from Crls1-deficiency. Mechanically, activating transcription factor 3 (ATF3) was identified as the key differentially expressed gene in Crls1-HKO mice through transcriptomic analysis, and our investigation further showed that CRLS1 suppressed ATF3 expression and inhibits its activity in palmitic acid-stimulated hepatocytes, while ATF3 partially reverses lipid accumulation and inflammation inhibited
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