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Tight junctions (TJs) are cell‑cell adhesion structures frequently altered by oncogenic transformation. In the present study the role of human papillomavirus (HPV) 16 E7 oncoprotein on the sealing of TJs was investigated and also the expression level of claudins in mouse cervix and in epithelial Madin‑Darby Canine Kidney (MDCK) cells. It was found that there was reduced expression of claudins ‑1 and ‑10 in the cervix of 7‑month‑old transgenic K14E7 mice treated with 17β‑estradiol (E2), with invasive cancer. In addition, there was also a
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