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Colombia passed Law 100 in 1993 with the goal of providing universal health care coverage, and by 2013, over 96% of the Colombian population had health insurance coverage. However, little is known about how health-related quality of life (HRQoL) and health literacy are related among those with the two most common types of health insurance coverage subsidised (those with lower incomes) and contributory (those with higher incomes) coverage. In the current exploratory investigation, data from adults visiting six primary care clinics in Col