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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the most popular ADHD treatment, since they're the most researched and have a rapid-acting effect. However, they aren't for everyone. These medications increase the signaling between nerves and areas in the brain to lessen symptoms of ADHD. These medications can also cause side-effects like a change in blood pressure or heart rate as well as an increase in appetite. Stimulants The most commonly used medication to