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It took centuries for this realization to open the way to use the testable brainstem centers to establish the criteria for a neurologic determination of death. The ontogenetic conclusion is that the brainstem is the ancestor of the developed human brain; the physiologic conclusion is that the brainstem is a vital center and a structural support system and conduit. When afunctional, life ends. Although the airway microbiota is a highly dynamic ecology, the role of longitudinal changes in airway microbiota during early childhood in asthma

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