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Data and information technology are key to every aspect of our response to the current COVID-19 pandemic-from how we diagnose patients and deliver care, to the development of predictive models of disease spread, to the management of personnel and equipment. The increasing engagement of informaticians at the forefront of these efforts has been a fundamental shift from an academic to an operational role. However, the past history of informatics as a scientific domain and an area of applied practice provides little guidan