https://www.selleckchem.com/pr....oducts/fen1-in-4.htm
Vitamin K antagonists (VKA) and non-vitamin K oral antagonist anticoagulants (NOAC) are used in the clinic to reduce risk of thrombosis. However, they also exhibit vascular off-target effects. The aim of this study is to compare VKA and NOAC on atherosclerosis progression and calcification in an experimental setup. Female Apoe mice (age 12weeks) were fed Western-type diet as control or supplemented with dabigatran etexilate or warfarin for 6 or 18weeks. Vascular calcification was measured in whole aortic arches using µCT and [ F]-NaF.
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