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Systematic reviews about the internal and marginal misfits of fixed prostheses have identified a limited number of clinical studies, suggesting the need for further research on the subject. Although the replica technique has been described as suitable for this purpose, few studies have validated it. The purpose of this invitro study was to compare the ability of a nondestructive replica technique and a destructive cementation technique to assess internal and marginal misfits of zirconia copings, considering current materials and designs