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Noteworthy, Cs improved the histopathological and behavioral factors in addition to mitigating advertisement hallmarks. In addition it exerted neuroprotection by lowering NF-κBp65 and TNF-α, while elevating Nrf2 and HO-1, along side stabilizing β-catenin underneath the effect of Jak2/PI3K/Akt/GSK-3β signaling. These beneficial ramifications of Cs had been abrogated by MLA co-administration signifying the α7-nAChR involvement in Cs-mediated impacts. Consequently, Cs can a
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