https://www.selleckchem.com/pr....oducts/PD-0332991.ht
miR-130b-5p was upregulated and IGFBP2 was downregulated in liver tissues of NAFLD mice. miR-130b-5p targeted IGFBP2 and downregulated its expression. MiR-130b-5p inhibition or IGFBP2 overexpression reduced the expression of SREBP-1, LXRa, ChREBP, SCD1, ACC1 and FAS, and levels of FBG, FINS and HOMA-IR while increasing the ratio of p-AKT/AKT in NAFLD mice. Overall, downregulation of miR-130b-5p can prevent hepatic lipid accumulation and insulin resistance in NAFLD by activating IGFBP2-dependent AKT pathway, highlighting the potential
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