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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person has both ADHD and depression or anxiety, treating one condition often improves the other. Mental health experts prescribe antidepressants and stimulants for depression or antidepressants in conjunction with ADHD medication. Wellbutrin (bupropion) and Effexor (venlafaxine) are the most commonly used antidepressants prescribed "off-label" for ADHD. These medications boost le