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The study can address time-consuming SNPs identification and also quantify the effect of SNP-SNP interactions.The synchronization control of two chaotic oscillatory systems is designed based on DNA strand displacement in the present work. Thus, combination synchronization of three 3-variable chaotic oscillatory systems is proposed based on DNA strand displacement. Firstly, five chemical reaction modules of double, displacement, adjustment, catalysis and degradation are designed. Based on these five modules, a 3-variable chaotic oscillatory