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Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic, and genetic perspectives. We used localized brain volume alterations to evaluate common and specific features of FTSD, FTSD-ALS, and ALS patients to further understand this clinical continuum. We used voxel-based morphometry on structural magnetic resonance images to localize volume alterations in group comparisons patients (20 FTSD, seven FTSD-ALS, and 18 ALS) vers
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