https://www.selleckchem.com/pr....oducts/muramyl-dipep
Aim Tuberculosis is the leading cause of mortality among infectious diseases worldwide. Finding a new competent anti tubercular therapy is essential. Materials methods We screened thousands of compounds and evaluated their efficacy against Mycobacterium tuberculosis. Results Initially, 2-nitronaphtho[2,3-b]benzofuran-6,11-dione was active against M. tuberculosis. Next, among 15 newly synthesized derivatives, BNF15 showed promising effect against all drug-sensitive and drug-resistant M. tuberculosis (MIC 0.02-0.78 μg/ml).
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