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Whether an anisotropically extended filamentous nanostructure can act as an effective scaffold for optimum inhibition of viral cellular accessory has not been examined. In this research, the preparation of a few sialyllactose-conjugated filamentous bacteriophages (SLPhages), with controlled running levels, ligand valencies, and two kinds of sialyllactose (α2,3' and α2,6', is demonstrated. With optimal ligand loading and valency, SLPhages revealed inhibitory activity (i